It is now possible to apply TMS directly on rodents with the new Cool-40 Rat Coil from MagVenture.
This gives you the possibility to study the effects of TMS within e.g. behavioral, metabolic, (epi) genetics, molecular, and biochemical pathways.
The Cool-40 Rat Coil is developed in close collaboration with leading researchers and is the first of its kind on the market specifically aimed at researchers working with animal models. The coil enables you to perform actual repetitive TMS protocols on rodents and obtain replicability and reliability in your research. A coil specifically designed for rodents eases the rTMS performance and the determination of the motor threshold.
Further, the coil has a size that fits into a PET or SPECT imaging scanner with a minimum ø120mm bore which for some research purposes is important.
Overcoming the barriers in TMS for rodents
The number of stimuli available in small coils like the Cool-40 Rat Coil is a huge barrier for performing real rTMS due to the heating of the coil. The Cool-40 Rat coil overcomes this barrier as it operates with the special High-Performance Cooling System. This will allow for a high number of stimuli before overheating.
The small dimensions of the rat brain compared to the human brain makes it very challenging to provide efficient TMS stimulation using human coils, as they typically lack focus of the magnetic fields and largely out-limit the dimensions of the rat's head. Further, the smaller coils that are currently available do not induce electrical fields in the brain that are comparable to the electrical fields elicited with human coils in the patient’s brain. All of these issues have been solved with the Cool-40 Rat coil due to the special design of the windings, the High-Performance Cooling System, and the bended shape.
Would you like to know more?
If you would like to know more about performing TMS on rodents; e.g. the possibilities, the constraints, the procedure, and/or technical information on the Cool-40 Rat coil, please feel free to contact either MagVenture or The Molecular Imaging Center Antwerp.